PolyGene is based in Switzerland. Founded in 2001, PolyGene is now one of the world top 5 professional transgenic service companies. For the generation of tailor-made animal models, PolyGene offers all standard services (classical transgenesis, blastocyst injection), but also state-of-the-art technologies such as CRISPR/Cas9, piggyBAC transgenesis, conditional and inducible gene knock-outs /-ins, gene humanization and cryopreservation. All services can be ordered in mice, but also in rats or rabbits. Inducible gene expression systems available at PolyGene allow to reversibly switch on/off gene expression in cell culture and in vivo, simply by adding or removing drugs such as RU486.